Didáctica de la música a través de las Tics.

El presente TFG tiene por principal objetivo estudiar la aplicación de las tecnologías en la educación musical en primaria. A través de la fundamentación teórica se muestra el impacto social y educativo de las tecnologías, así como los beneficios e inconvenientes de su incorporación en el aula. Observado el potencial motivador y la posibilidad de despertar interés por los aprendizajes que tiene el uso de las TICs se ha realizado una propuesta de intervención educativa para un contexto concreto de quinto y sexto de Primaria. La propuesta combina metodologías tanto de corte tradicional como innovador con un uso estratégico de diferentes planteamientos y aplicaciones del mundo TICs como metodología activa. Esta propuesta plantea el desarrollo competencial previsto por el plan educativo y hace accesibles una serie de contenidos y desarrollo de herramientas de manera igualitaria al llevarse a cabo con la dotación propia del centro a disposición de todo el alumnado.Grado en Educación Primari

A learning algorithm for visual pose estimation of continuum robots

Continuum robots offer significant advantages for surgical intervention due to their down-scalability, dexterity, and structural flexibility. While structural compliance offers a passive way to guard against trauma, it necessitates robust methods for online estimation of the robot configuration in order to enable precise position and manipulation control. In this paper, we address the pose estimation problem by applying a novel mapping of the robot configuration to a feature descriptor space using stereo vision. We generate a mapping of known features through a supervised learning algorithm that relates the feature descriptor to known ground truth. Features are represented in a reduced sub-space, which we call eigen-features. The descriptor provides some robustness to occlusions, which are inherent to surgical environments, and the methodology that we describe can be applied to multi-segment continuum robots for closed-loop control. Experimental validation on a single-segment continuum robot demonstrates the robustness and efficacy of the algorithm for configuration estimation. Results show that the errors are in the range of 1°

Holocene hydroclimate changes in continental Croatia recorded in speleothem δ13C and δ18O from Nova Grgosova Cave

We present the first stable isotope (δ13C and δ18O) speleothem record from continental Croatia retrieved from two coeval stalagmites from Nova Grgosova Cave. U-Th dates constrain the stalagmite growth history from 10ka to the present, revealing coeval growth between 7.8 and 5.6ka. We interpret δ18O as an autumn/winter hydrological proxy related to changes of vapor source, precipitation amount, and/or seasonal rainfall distribution, while δ13C predominantly responds to spring/summer vegetation status and soil microbial activity. We identify several centennial to millennial-scale hydroclimate oscillations during this period that result from multiple forcing factors. Along with amount and source effect, it appears that some centennial variations were governed also by seasonal moisture balance. From 9.2 to 8.8ka BP, the local environmental setting was characterized by enhanced vegetation activity, while during the 8.2ka event the main feature was a change in precipitation seasonality. The most prominent change, identified in both δ13C records, is a sudden decline of vegetation and soil biological activity around 7.4 ka, indicating a precipitation decrease at a time of maximum plant growth in spring and summer and likely also reduced precipitation in autumn and winter. Although small in magnitude in these speleothems, a peak in δ18O and δ13C values at 4.3–4.1ka suggests that both summer and winter conditions were substantially drier during the 4.2ka event, in accordance with increased Mediterranean aridity and consistent with other global climate changes reported at this time. Compared to the present North Atlantic Oscillation (NAO) influence, we assume that millennial Holocene NAO-like variations were persistent through the Holocene via their effect on modifying local/regional air temperature, vapor origin, and inter- and intrannual precipitation distribution. Anthropogenic deforestation, which was the first major human impact on the environment during the Neolithic agricultural revolution, is excluded as a leading factor in δ13C variability since the first sedentary settlements were established further to the east in more arable locations along river valleys. However, the impact of intensive mining around the cave site during the last millennium is evident, with substantial deforestation driving an increase in δ13C

Staple-based paper electrochemical platform for celiac disease diagnosis

A staple-based electrochemical platform is proposed for the first time as a simple and low-cost detection system for paper-based devices. The system, that incorporates small and disposable stainless-steel staples as electrodes (modified with carbon ink in the case of the working electrode) is combined with a paper strip and is carefully optimized with ferrocene carboxylic acid. As a proof-of-concept, it was employed for the enzymatic (HRP-based) immunoelectroanalytical detection of human tissue anti-transglutaminase (anti-tTG), biomarker for celiac disease diagnosis. The intensity of the current due to the electrochemical reduction of TMB (HRP substrate) was recorded chronoamperometrically at -0.2 V in different paper areas. A linear relationship between the current measured at 30 s and the logarithm of the concentration of anti-tTG in the range comprised between 3 and 100 U.mL-1 was obtained. Negative and positive controls produced expected values. Results demonstrated that the paper/staple-combined platform is very convenient for the detection of electroactive analytes and other compounds that can be determined indirectly in bioassays.Fil: Nanni, Paula Inés. Universidad de Oviedo; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; ArgentinaFil: Gonzalez Lopez, Andrea. Universidad de Oviedo; EspañaFil: Nuñez Bajo, Estefanía. Universidad de Oviedo; EspañaFil: Madrid, Rossana Elena. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Fernandez Abedul, M. Teresa. Universidad de Oviedo; Españ

Tide-surge-wave modelling and forecasting in the Mediterranean Sea with focus on the Italian coast

Abstract A tide-surge-wave modelling system, called Kassandra, was developed for the Mediterranean Sea. It consists of a 3-D finite element hydrodynamic model (SHYFEM), including a tidal model and a third generation finite element spectral wave model (WWMII) coupled to the hydrodynamic model. The numerical grid of the hydrodynamic and wave models covers the whole Mediterranean with variable resolution. The comparison with coastal tide gauge stations along the Italian peninsula results in a root sum square error for the main tidal components equal to 1.44 cm. The operational implementation of the Kassandra storm surge system through the use of a high resolution meteorological model chain (GFS, BOLAM, MOLOCH) allows accurate forecast of total water level and wave characteristics. The root mean square error for the first day of forecast is 5 cm for the total water level and 22 cm for the significant wave height. Simulation results indicate that the use of a 3-D approach with a depth-varying loading factor and the inclusion of the non-linear interaction between tides and surge improve significantly the model performance in the Italian coast

A time-space window between Eocene karst bauxite genesis and the first molasse deposition in the Dinaric Foreland Basin in the North Dalmatia, Croatia

Karst bauxite deposits in the North Dalmatian piggyback basin (NDPGB) are a part of the Mediterranean bauxite belt, which is the largest European bauxite deposit zone; however, there is a general lack of information regarding the genesis, age, and precursor of the bauxite deposits in this region. In this study, we combined detrital zircon U–Pb geochronology with compositional, mineralogical, and morphological data from four bauxite locations in the NDPGB to provide a new palaeogeographical and palaeoenvironmental evolution model for the Lutetian–Rupelian timeframe of the NDPGB. The Eocene climatic conditions began with the Palaeocene–Eocene Thermal Maximum event (∼56 Ma), followed by the Early Eocene Climatic Optimum (∼49 Ma) and Middle Eocene Climatic Optimum (∼40 Ma), and were completed as a cooling trend culminating around the Eocene/Oligocene boundary (∼34 Ma), with a shift towards an icehouse climate. These events were coeval with the continuous drift of the African continent towards Eurasia and the subsequent closure of the western part of the former Neo-Tethys Ocean associated with massive volcanic activity. Based on the bauxite deposits of the NDPGB, Early Eocene limestones formed in the last phase of the long-lasting Adriatic Carbonate Platform. The Middle Eocene orogenic activity resulted in an elevation in this area. High average temperatures, accelerated hydrological cycles and precipitation, and intensive continental weathering with increased volcanic carbon input resulted in favourable conditions for the development of karst bauxites at this time. Further Upper Eocene tectonic deformation of the NDPGB area resulted in the development of bauxite traps and enabled redeposition of the initial bauxite material. Subsequently, the bauxite deposits were covered with clastic carbonate molasse derived from the intensive erosion of the young Dinaric orogeny. The implications of this study are as follows. First, it provides new information on the timing of bauxitisation in the area by providing the first radiometric zircon geochronology, which refined and restricted the time window for bauxite formation in this region. Additionally, our results provide a new perspective on the possibility of aeolian precursors in karst bauxite formation and provide new constraints on the first tectonic marks of the initial Dinaric orogeny

A time-space window between Eocene karst bauxite genesis and the first molasse deposition in the Dinaric Foreland Basin in the North Dalmatia, Croatia

Karst bauxite deposits in the North Dalmatian piggyback basin (NDPGB) are a part of the Mediterranean bauxite belt, which is the largest European bauxite deposit zone; however, there is a general lack of information regarding the genesis, age, and precursor of the bauxite deposits in this region. In this study, we combined detrital zircon U–Pb geochronology with compositional, mineralogical, and morphological data from four bauxite locations in the NDPGB to provide a new palaeogeographical and palaeoenvironmental evolution model for the Lutetian–Rupelian timeframe of the NDPGB. The Eocene climatic conditions began with the Palaeocene–Eocene Thermal Maximum event (∼56 Ma), followed by the Early Eocene Climatic Optimum (∼49 Ma) and Middle Eocene Climatic Optimum (∼40 Ma), and were completed as a cooling trend culminating around the Eocene/Oligocene boundary (∼34 Ma), with a shift towards an icehouse climate. These events were coeval with the continuous drift of the African continent towards Eurasia and the subsequent closure of the western part of the former Neo-Tethys Ocean associated with massive volcanic activity. Based on the bauxite deposits of the NDPGB, Early Eocene limestones formed in the last phase of the long-lasting Adriatic Carbonate Platform. The Middle Eocene orogenic activity resulted in an elevation in this area. High average temperatures, accelerated hydrological cycles and precipitation, and intensive continental weathering with increased volcanic carbon input resulted in favourable conditions for the development of karst bauxites at this time. Further Upper Eocene tectonic deformation of the NDPGB area resulted in the development of bauxite traps and enabled redeposition of the initial bauxite material. Subsequently, the bauxite deposits were covered with clastic carbonate molasse derived from the intensive erosion of the young Dinaric orogeny. The implications of this study are as follows. First, it provides new information on the timing of bauxitisation in the area by providing the first radiometric zircon geochronology, which refined and restricted the time window for bauxite formation in this region. Additionally, our results provide a new perspective on the possibility of aeolian precursors in karst bauxite formation and provide new constraints on the first tectonic marks of the initial Dinaric orogeny

Evidence from Family Studies for Autoimmunity in Arrhythmogenic Right Ventricular Cardiomyopathy: Associations of Circulating Anti-Heart and Anti-Intercalated Disk Autoantibodies with Disease Severity and Family History

Background: Serum anti-heart autoantibodies (AHA) and anti-intercalated disk autoantibodies (AIDA) are autoimmune markers in myocarditis. In arrhythmogenic right ventricular cardiomyopathy (ARVC) myocarditis has been reported. To provide evidence for autoimmunity, we searched for AHA and AIDA in ARVC. Methods: We studied: 42 ARVC probands, 23 male, aged 42, interquartile range (IQR) 33;49, 20 from familial and 22 non-familial pedigrees; 37 clinically affected relatives (AR), 24 male aged 35, IQR 18;46; 96 healthy relatives (HR), 49 male, aged 27, IQR 17;45. Serum AHA and AIDA were tested by indirect immunofluorescence on human myocardium and skeletal muscle in 171 of the 175 ARVC individuals and in controls with: non-inflammatory cardiac disease (NICD) (n=160), ischemic heart failure (IHF) (n=141), normal blood donors (NBD) (n=270). Screening of five desmosomal genes was performed in probands; when a sequence variant was identified, cascade family screening followed, blind to immunological results. Results: AHA frequency was higher (36.8%) in probands, AR (37.8%) and HR (25%) than in NICD (1%), IHF (1%) or NBD (2.5%) (p=0.0001). AIDA frequency was higher in probands (8%, p=0.006), in AR (21.6%, p=0.00001) and in HR (14.6% p=0.00001) than in NICD (3.75%), IHF (2%) or NBD (0.3%). AHA positive status was associated with higher frequency of palpitation (p=0.004), ICD implantation (p=0.021), lower left ventricular ejection fraction (LVEF) (p=0.004), AIDA positive status with both lower RV and LVEF (p=0.027 and p=0.027 respectively). AHA and/or AIDA positive status in the proband and/or at least one of the respective relatives was more common in familial (17/20, 85%) than in sporadic (10/22, 45%) pedigrees (p=0.007). Conclusions: Presence of AHA and AIDA provides evidence of autoimmunity in the majority of familial and in almost half of sporadic ARVC. In probands and in AR these antibodies were associated with disease severity features; longitudinal studies are needed to clarify whether they may predict ARVC development in HR or if they be a result of manifest ARVC

SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice

Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition has become an attractive therapeutic strategy to preserve axons in a variety of disorders of the peripheral (PNS) and central nervous system (CNS). While SARM1 has been extensively studied in neurons, it remains unknown whether SARM1 is present and functional in myelinating glia? This is an important question to address. Firstly, to identify whether SARM1 dysfunction in other cell types in the nervous system may contribute to neuropathology in SARM1 dependent diseases? Secondly, to ascertain whether therapies altering SARM1 function may have unintended deleterious impacts on PNS or CNS myelination? Surprisingly, we find that oligodendrocytes express sarm1 mRNA in the zebrafish spinal cord and that SARM1 protein is readily detectable in rodent oligodendrocytes in vitro and in vivo. Furthermore, activation of endogenous SARM1 in cultured oligodendrocytes induces rapid cell death. In contrast, in peripheral glia, SARM1 protein is not detectable in Schwann cells and satellite glia in vivo and sarm1/Sarm1 mRNA is detected at very low levels in Schwann cells, in vivo, in zebrafish and mouse. Application of specific SARM1 activators to cultured mouse Schwann cells does not induce cell death and nicotinamide adenine dinucleotide (NAD) levels remain unaltered suggesting Schwann cells likely contain no functionally relevant levels of SARM1. Finally, we address the question of whether SARM1 is required for myelination or myelin maintenance. In the zebrafish and mouse PNS and CNS, we show that SARM1 is not required for initiation of myelination and myelin sheath maintenance is unaffected in the adult mouse nervous system. Thus, strategies to inhibit SARM1 function to treat neurological disease are unlikely to perturb myelination in humans.CM was funded by a Medical Research Council (UK) studentship (2251399). PA-F (206634/Z/17/Z), AL (210904/Z/18/Z), CC (220027/Z/19/Z), RB (203151/Z/16/Z) and MC (220906/Z/20/Z) were funded by the Wellcome Trust (UK). BS was supported by a Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (109408/Z/15/Z). KM was funded by the National Institute of Neurological Disorders and Stroke Awards (R01NS079445). JG-S was funded by a Miguel Servet Fellowship (CP22/00078) from the Instituto de Salud Carlos III and the Millennium Nucleus for the Study of Pain (MiNuSPain), Santiago, Chile. HC was funded by the Spanish “Ministerio de Economía y Competitividad” (BFU2016-75864R and PID2019-109762RB-I00), ISABIAL (UGP18-257 and UGP-2019-128), and Generalitat Valenciana (PROMETEO 2018/114). Y-PH and C-YC were funded by Academia Sinica, AS-IA-106-L04 to Y-PH.Peer reviewe